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基于代杂化颗粒技术的 XTerra® 系列高效液相色谱柱, 可以让色谱工作者在药物发现，方法开发和纯化分离领域使用高pH值流动相。
§ XTerra颗粒能耐受二甲基亚砜（DMSO）溶剂，可延长高通量药物发现研究中色谱柱的寿命。
§ 宽pH 范围使得方法开发研究人员在所需的pH值条件下操作，以获得选择性。
§ 高载荷量使得分离纯化的科学家在高pH值条件下，在纯化碱性化合物时，一次进样量增加六十倍。
XTerra® MS、Shield RP和苯基色谱柱将硅胶和聚合物键合相的 佳性能与的杂化颗粒技术相结合，在颗粒合成中每三个硅 烷醇中有一个被替换成甲基基团。这个步骤只能在颗粒合成的 起始阶段完成，加入的此甲基基团是碱性颗粒骨架的组成部分。 由此可生成机械强度大的颗粒，适用于高pH值条件下的分离，提 高碱性化合物的上样量和峰形。
XTerra® RP18和RP8色谱柱将内嵌极性基团的屏蔽技术与杂化颗粒技术结合起来，可以获得对称的色谱峰形。这一通用型色谱柱以*的选择性为快速方法开发提供了一个强有力的工具。同其它所有XTerra® 色谱柱一样，利用屏蔽技术的XTerra® RP色谱柱展现了极其的水浸润性，即便是使用*的水溶液作为流动相，亦可获得稳定的色谱结果。大大拓宽的pH范围，为选择性调节提供了有效途径；加上选择性互补的MS和RP两种键合相更是增加了选择性的调节范围，是成功进行方法开发*的工具。
A simple method is presented for the simultaneous determination of morphine, 6-acetylmorphine, codeine, cocaine, benzoylecgonine, cocaethylene, methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in vitreous humor by high-performance liquid chromatography with photodiode array detector after solid-phase extraction with Oasis® HLB cartridges and dichloromethane as eluent. The chromatographic process was carried out using an XTerra® RP8 column (250 × 4.6 mm i.d., 5 µm particle size) and a phase composed of acetonitrile and pH 6.5 phosphate buffer in gradient mode. A linear response from the detector was obtained within the concentration range of 0.1-4 µg ml(-1) , with correlation coefficients higher than 0.99. The limits of detection were lower than 30 ng ml(-1) for all the drugs studied, the coefficients of variation fluctuated between 0.1 and 12.4%, and the average recoveries were higher than 78% for all the drugs except for EDDP, with a value of 66.4%. Finally, the proposed method was applied to 15 vitreous humor samples coming from individuals who had died from opiate and/or cocaine overdose, showing consumption of cocaine in 14 cases, methadone in five cases and heroin in three cases. Average concentrations of 0.30 µg ml(-1) for morphine, 0.24 µg ml(-1) for 6-acetylmorphine, 0.10 µg ml(-1) for codeine, 0.81 µg ml(-1) for cocaine, 1.26 µg ml(-1) for benzoylecgonine, 0.15 µg ml(-1) for cocaethylene, 0.11 µg ml(-1) for methadone and 0.68 µg ml(-1) for EDDP were obtained.
| 品名 | 编号 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 19 mm X 150 mm, 1/pkg | 186002258 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 150 mm, 1/pkg | 186000493 |
| XTerra RP 8 Column, 125Å, 5 µm, 3 mm X 150 mm, 1/pkg | 186000473 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 30 mm X 300 mm, 1/pkg | 186002278 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 50 mm X 250 mm, 1/pkg | 186002850 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 150 mm, 1/pkg | 186000457 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 30 mm X 100 mm, 1/pkg | 186001945 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 100 mm, 1/pkg | 186000453 |
| XTerra RP 8 Column, 125Å, 3.5 µm, 4.6 mm X 50 mm, 1/pkg | 186000435 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 30 mm X 250 mm, 1/pkg | 186002274 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 30 mm X 150 mm, 1/pkg | 186002270 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 30 mm, 1/pkg | 186001911 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 250 mm, 1/pkg | 186000497 |
| XTerra RP 8 Column, 125Å, 5 µm, 3.9 mm X 150 mm, 1/pkg | 186000481 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 250 mm, 1/pkg | 186000461 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 19 mm X 100 mm, 1/pkg | 186001937 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 19 mm X 150 mm, 1/pkg | 186002382 |
| XTerra RP 8 Column, 125Å, 5 µm, 3 mm X 100 mm, 1/pkg | 186000469 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 50 mm X 150 mm, 1/pkg | 186002846 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 50 mm, 1/pkg | 186000485 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 50 mm, 1/pkg | 186000449 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 19 mm X 250 mm, 1/pkg | 186002262 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 100 mm, 1/pkg | 186000489 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 50 mm X 50 mm, 1/pkg | 186002282 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 19 mm X 300 mm, 1/pkg | 186002266 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 5 µm, 19 mm X 10 mm, 1/pkg | 186001107 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 10 µm, 19 mm X 10 mm, 1/pkg | 186001037 |
| XTerra RP 8 Prep Column, 125Å, 5 µm, 7.8 mm X 50 mm, 1/pkg | 186001155 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 10 µm, 7.8 mm X 10 mm, 1/pkg | 186001175 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 5 µm, 7.8 mm X 10 mm, 1/pkg | 186001171 |
| XTerra Shield RP18 Column, 125Å, 3.5 µm, 2.1 mm X 150 mm, 1/pkg | 186000410 |
| XTerra Shield RP18 Column, 125Å, 3.5 µm, 2.1 mm X 20 mm, 1/pkg | 186001925 |
| XTerra RP18 Prep Guard Cartridge, 125Å, 10 µm, 30 mm X 10 mm, 1/pkg | 186006905 |
| XTerra RP18 Prep Guard Cartridge, 125Å, 5 µm, 30 mm X 10 mm, 1/pkg | 186006906 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 30 mm X 50 mm, 1/pkg | 186001941 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 30 mm X 75 mm, 1/pkg | 186002390 |
| XTerra RP 8 Prep Column, 125Å, 5 µm, 7.8 mm X 100 mm, 1/pkg | 186001159 |
| XTerra RP 8 Prep Column, 125Å, 5 µm, 7.8 mm X 150 mm, 1/pkg | 186001478 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 10 µm, 10 mm X 10 mm, 1/pkg | 186001009 |
| XTerra Shield RP18 Cartridge, 125Å, 5 µm, 4.6 mm X 150 mm, 1/pkg | 186000580 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 5 µm, 10 mm X 10 mm, 1/pkg | 186001008 |
| XTerra Shield RP18 Column, 125Å, 3.5 µm, 2.1 mm X 100 mm, 1/pkg | 186000406 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 5 µm, 3.9 mm X 5 mm, 3/pkg | 186007947 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 5 µm, 2.1 mm X 5 mm, 3/pkg | 186007945 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 3.5 µm, 3.9 mm X 5 mm, 3/pkg | 186007943 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 50 mm X 100 mm, 1/pkg | 186002225 |
| XTerra RP 8 Prep Column, 125Å, 10 µm, 7.8 mm X 150 mm, 1/pkg | 186001163 |
| XTerra RP 8 Prep Column, 125Å, 10 µm, 7.8 mm X 300 mm, 1/pkg | 186001167 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 50 mm X 50 mm, 1/pkg | 186002221 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 3.5 µm, 2.1 mm X 5 mm, 3/pkg | 186007941 |
